重组小鼠 IgG3 Fc蛋白 | Syd Labs BP4124
重组小鼠 IgG3 Fc蛋白,体内实验级(In Vivo Grade Recombinant Mouse IgG3 Fc Protein)。体内实验级重组natural和engineered小鼠 IgG3 Fc蛋白(mIgG3 Fc)(In vivo grade recombinant natural and engineered Mouse IgG3 Fc proteins (mIgG3 Fc)),和重组小鼠 IgG3同型对照抗体和突变体(recombinant Mouse IgG3 isotype control antibody and mutants)是可用的。生物素化的mIgG3 Fc和带有Avi-, His-和flag -tags的mIgG3 Fc也可用。
产品参数
| 货号 | BP4124 |
|---|---|
| 产品名称 | 重组小鼠 IgG3 Fc蛋白 | Syd Labs BP4124 |
| 英文名 | In Vivo Grade Recombinant Mouse IgG3 Fc Protein |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | 小鼠Fc蛋白IgG3),小鼠 IgG3 Fc region,重组mIgG3 Fc蛋白 |
| 概述 | 重组natural和engineered小鼠 IgG3 Fc蛋白(mIgG3 Fc),体内实验级(In vivo grade recombinant natural and engineered Mouse IgG3 Fc proteins (mIgG3 Fc)),和重组小鼠 IgG3同型对照抗体和突变体(recombinant Mouse IgG3 isotype control antibody and mutants)是可用的。生物素化的mIgG3 Fc和带有Avi-, His-和flag -tags的mIgG3 Fc也可用。 |
| 抗体形式 | 0.2 μM过滤溶液,1x PBS |
| 内毒素 | 根据 LAL 方法,≤ 1 EU每 1 mg 蛋白质。提供特级体内实验级重组小鼠 IgG3 Fc蛋白(In Vivo Grade Recombinant Mouse IgG3 Fc Protein,内毒素≤0.05 EU/mg)。 |
| 纯度 | >95%(在还原条件下通过SDS-PAGE测定) |
| 运输 | 重组小鼠 IgG3 Fc蛋白,体内实验级(In Vivo Grade Recombinant Mouse IgG3 Fc Protein)用冰袋运输。收到后,请立即将其存放在下面建议的温度下。 |
| 稳定性与存储 | 使用手动除霜冰箱并避免重复冻融循环。 如果保存在2 至 8°C,自收到之日起可保存3个月。如果保存在-20 至 -70°C,自收到之日起可保存 12个月。 |
| 注意事项 | BP4124 Syd Labs重组natural和engineered小鼠 IgG3 Fc蛋白(mIgG3 Fc),体内实验级(In vivo grade recombinant natural and engineered Mouse IgG3 Fc proteins (mIgG3 Fc)),和重组小鼠 IgG3同型对照抗体和突变体(recombinant Mouse IgG3 isotype control antibody and mutants)是可用的。生物素化的mIgG3 Fc和带有Avi-, His-和flag -tags的mIgG3 Fc也可用。 |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品,不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题,欢迎随时联系Syd Labs国内市场推广合作伙伴:武汉多找找科技有限公司,企业微信:duozhaozhao2024 联系电话:18162581039(龙经理) |
文献
BP4124:重组小鼠 IgG3 Fc蛋白,体内实验级(In Vivo Grade Recombinant Mouse IgG3 Fc Protein)
提供体内实验级重组天然及工程化小鼠IgG3 Fc蛋白(mIgG3 Fc),以及重组小鼠IgG3同型对照抗体和突变体。同时提供生物素化mIgG3 Fc,以及带有Avi、His和DYKDDDDK标签的mIgG3 Fc。欢迎联系我们索取工程化小鼠IgG3 Fc蛋白、生物素化mIgG3 Fc以及带Avi、His和DYKDDDDK标签的小鼠IgG3 Fc的报价。重组小鼠IgG3 Fc蛋白及突变体可作为各种体外和体内实验中小鼠IgG3抗体及mIgG3 Fc融合蛋白的同型对照。
小鼠 IgG3 Fc蛋白部分参考文献:
1. Affinity of human IgG subclasses to mouse Fc gamma receptors.
Dekkers, G., et al. mAbs. 2017;9(5):810-819. PMID: 28463043
“No binding of mouse IgG1 to FcγRI and FcγRIV, no binding of mouse IgG2b to FcγRIII, and no binding of mouse IgG3 to any mouse FcγR was detected…”
2. Mouse IgG3 binding to macrophage-like cells is prevented by deglycosylation of the antibody or by Accutase treatment of the cells.
Klaus, T., et al. Sci Rep. 2021 May 13;11(1):10279. PMID: 33986405
“The study confirmed that J774A.1 cells express a receptor binding antigen-free mouse IgG3, as reported by Saylor et al. Deglycosylation of mouse IgG3 prevented its binding…”
3. The generation and evaluation of two panels of epitope-matched mouse IgG1, IgG2a, IgG2b and IgG3 antibodies specific for Plasmodium falciparum and Plasmodium yoelii merozoite surface protein 1–19 (MSP119).
Couper, K. N., et al. Exp Parasitol. 2012 Jun;131(2):180-9. PMID: 22425391
“Mouse IgG1, IgG2a, IgG2b, and IgG3 specific for the C-terminal 19-kDa region of Plasmodium falciparum and Plasmodium yoelii MSP119 were generated to study protective mechanisms…”
4. Agglutinating mouse IgG3 compares favourably with IgMs in typing of the blood group B antigen: Functionality and stability studies.
Klaus, T., et al. Sci Rep. 2016 Aug 2;6:30938. PMID: 27480384
“Mouse IgG3 antibodies uniquely form oligomers upon antigen binding through their Fc fragment. Divalent F(ab′)2 from pepsin-digested M18 retained agglutination capability…”
5. Properties of mouse and human IgG receptors and their contribution to disease models.
Bruhns, P., et al. Blood. 2012 Jun 14;119(24):5640-9. PMID: 22596262
“FcγRI is a high-affinity receptor for mouse IgG2a and a low-affinity receptor for mouse IgG2b and IgG3. All activating mouse FcγRs (FcγRI, FcγRIII, FcγRIV) bind IgG2a and IgG2b…”

