[KO Validated] CDKN1A/p21 Rabbit mAb (A19094)
(悉得)Syd Labs [KO Validated] CDKN1A/p21 Rabbit mAb(Catalog Number: A19094) encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1.
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货号 | A19094 |
---|---|
产品名称 | [KO Validated] CDKN1A/p21 Rabbit mAb (A19094) |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 |
基因名称 | CDKN1A |
蛋白名 | CDKN1A |
Uniprot/Swissprot ID | P38936 |
Entrez GeneID | 1026 |
克隆号 | ARC51040 |
克隆性 | Monoclonal |
来源 | Rabbit |
反应性 | Human, Mouse, Rat |
偶联 | Unconjugated |
注意事项 | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
产品咨询 | 悉得(Syd Labs)在国内只通过代理商销售其产品,不做直销。终端用户咨询价格请联系悉得(Syd Labs)中国代理商。 关于悉得(Syd Labs)产品如果有任何技术或其它问题,欢迎随时联系悉得(Syd Labs)国内市场推广合作伙伴:武汉多找找科技有限公司,企业微信:duozhaozhao2024 联系电话:18162581039(龙经理) |
描述
A19094: [KO Validated] CDKN1A/p21 Rabbit mAb
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
Immunogen Information about [KO Validated] CDKN1A/p21 Rabbit mAb (A19094)
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human CDKN1A/p21CIP1 (NP_000380.1).
Sequence: MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
Gene ID: 1026
Swiss prot: P38936
Synonyms: P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; 21
Calculated MW: 18kDa
Observed MW: 21kDa/18kDa
Please remember our product information: [KO Validated] CDKN1A/p21 Rabbit mAb(Catalog Number: A19094) (悉得)Syd Labs