IRF2 Polyclonal Antibody

IRF2 Polyclonal Antibody

In stock

Conditions of optimal IRF2 polyclonal antibody performance should be determined experimentally by the investigator.

SKU: PA002070-PA1818 分类: ,
货号 PA002070-PA1818
产品名称IRF2 Polyclonal Antibody
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 IRF2, Interferon regulatory factor 2
同种型 Rabbit IgG.
反应性 Human, Rat, Mouse.
免疫源 A synthetic peptide corresponding to a sequence at the C-terminal of human IRF2, identical to the related rat sequence and different from the related mouse sequence by one amino acid.
纯化 Immunogen affinity purified.
抗体形式 Lyophilized.
稳定性与存储 Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
注意事项 Conditions of optimal IRF2 antibody performance should be determined experimentally by the investigator.
线下下单 Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

描述

PA002070-PA1818: IRF2 Polyclonal Antibody
Introduction
IRF2(interferon regulatory factor 2) is a member of the interferon regulatory transcription factor (IRF) family. The IRF2 gene is mapped on 4q35.1. when the IRF2 gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice. One IRF binding site was found within the IRF2 promoter, and expression of the IRF2 gene was affected by both transient and stable IRF1 expression. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. Irf2 was required to prevent NK-cell apoptosis and keep immature NK cells alive, thus promoting NK-cell maturation and their supply to peripheral blood.
Other IRF2 Antibody:
IRF2 Polyclonal Antibody

IRF2 Protein:
Recombinant Human IRF2

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