EIF4G2 Polyclonal Antibody

EIF4G2 Polyclonal Antibody

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Conditions of optimal EIF4G2 polyclonal antibody performance should be determined experimentally by the investigator.

SKU: PA001547-C13062 分类: ,
货号 PA001547-C13062
产品名称EIF4G2 Polyclonal Antibody
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 DAP5, Death associated protein 5, EIF4G2, Eukaryotic translation initiation factor 4 gamma 2, IF4G2, NAT1
特异性 EIF4G2 antibody detects endogenous levels of total EIF4G2 protein.
反应性 Human, Mouse.
免疫源 The antiserum was produced against synthesized peptide derived from internal of human EIF4G2.
纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体形式 Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
稳定性与存储 Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
注意事项 Conditions of optimal EIF4G2 antibody performance should be determined experimentally by the investigator.
线下下单 Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

描述

PA001547-C13062: EIF4G2 Polyclonal Antibody
Introduction
Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene. Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Other EIF4G Antibody:
eIF4G (Ab-1108) Polyclonal Antibody

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