EIF2AK1 Polyclonal Antibody
Conditions of optimal EIF2AK1 polyclonal antibody performance should be determined experimentally by the investigator.
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货号 | PA001539-R12-2739 |
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产品名称 | EIF2AK1 Polyclonal Antibody |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | Eukaryotic translation initiation factor 2-alpha kinase 1,EC 2.7.11.1 |
特异性 | EIF2AK1 antibody detects endogenous levels of EIF2AK1. |
反应性 | Human, Mouse. |
免疫源 | The antiserum was produced against synthesized peptide derived from human EIF2AK1. |
纯化 | The antibody was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography. |
抗体形式 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
稳定性与存储 | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
注意事项 | Conditions of optimal EIF2AK1 antibody performance should be determined experimentally by the investigator. |
线下下单 | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
描述
PA001539-R12-2739: EIF2AK1 Polyclonal Antibody
Background
EIF2AK1 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1), also called HRI, is an enzyme that in humans is encoded by the EIF2AK1 gene. Hartz (2010) mapped the EIF2AK1 gene to chromosome 7p22.1 based on an alignment of the EIF2AK1 sequence with the genomic sequence. Chen and London (1995) reviewed the activation and control of rat and rabbit Hri. Hri functions as a dimer, and its activation involves autophosphorylation, which requires an invariant lysine in kinase domain II. Using cDNA arrays and Northern blot analysis, Hwang et al. (2000) found that HRI was downregulated in the majority of ovarian cancers examined compared with normal ovarian tissues.
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