CYB5R1 Polyclonal Antibody
Conditions of optimal CYB5R1 polyclonal antibody performance should be determined experimentally by the investigator.
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货号 | PA001359-R12-2663 |
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产品名称 | CYB5R1 Polyclonal Antibody |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | NADH-cytochrome b5 reductase 1,EC 1.6.2.2; b5R.1; NAD(P)H:quinone oxidoreductase type 3 polypeptide A2; Humb5R2 |
特异性 | CYB5R1 antibody detects endogenous levels of CYB5R1. |
反应性 | Human, Mouse, Rat. |
免疫源 | The antiserum was produced against synthesized peptide derived from human CYB5R1. |
纯化 | The antibody was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography. |
抗体形式 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
稳定性与存储 | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
注意事项 | Conditions of optimal CYB5R1 antibody performance should be determined experimentally by the investigator. |
线下下单 | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
描述
PA001359-R12-2663: CYB5R1 Polyclonal Antibody
Introduction
NADH-cytochrome b5 reductase 1 (CYB5R1) belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. This reductase contains 1 FAD-binding FR-type domain and is involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Cytochrome b5 reductase, a flavoprotein that has an NADH binding site, can provide electrons to p450 monooxygenases through cytochrome b5. Reactions catalyzed by P450 show that the properties of the associated electron transport proteins that support P450-1 activity in mutants are consistent with cytochroe b5: NADH-cytochrome b5 oxidoreductase (cyt b5: cyt b5 reductase). Experiments have indicated that a flavoprotein is involved in the reaction that GA12 synthesis from GA12-aldehyde and consistent with participation of cytochrome b5 reductase which has an FAD prosthetic group. Added cytochrome b5 would enhance coupling of cytochrome b5 reductase to the P450-1 monooxygenase facilitating electron transport, while added FAD would restore bound flavin that may have been lost from the cyt b5 reductase during microsome preparation.
Other CYB5R1 Antibody:
CYB5R1 Polyclonal Antibody