CXCR7 Polyclonal Antibody

CXCR7 Polyclonal Antibody

In stock

Conditions of optimal CXCR7 polyclonal antibody performance should be determined experimentally by the investigator.

SKU: PA001356-G065 分类: ,
货号 PA001356-G065
产品名称CXCR7 Polyclonal Antibody
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; G-protein coupled receptor RDC1 homolog; RDC-1; Chemokine orphan receptor 1
特异性 CXCR7 antibody detects endogenous levels of total CXCR7 protein.
反应性 Human, Mouse, Rat.
免疫源 The antiserum was produced against synthesized peptide derived from C-terminal of human CXCR7.
纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体形式 Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
稳定性与存储 Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
注意事项 Conditions of optimal CXCR7 antibody performance should be determined experimentally by the investigator.
线下下单 Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

描述

PA001356-G065: CXCR7 Polyclonal Antibody
Introduction
C-X-C chemokine receptor type 7 (CXCR-7) is a protein that in humans is encoded by the CXCR7 gene. This gene encodes a member of the G-protein coupled receptor family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12. However, another recent study has provided evidence that ligand binding to CXCR7 activates MAP kinases through Beta-arrestins, and thus has functions beyond ligand sequestration.
Other CXCR7 Antibody:
CXCR7 Polyclonal Antibody

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