SKP2 Polyclonal Antibody

SKP2 Polyclonal Antibody

In stock

Conditions of optimal SKP2 polyclonal antibody performance should be determined experimentally by the investigator.

SKU: PA000235-PA1102 分类: ,
货号 PA000235-PA1102
产品名称SKP2 Polyclonal Antibody
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 S-phase kinase-associated protein 2 Antibody
同种型 Rabbit IgG.
特异性 Human, mouse, rat. No cross reactivity with other proteins.
反应性 Human, Mouse, Rat.
免疫源 A synthetic peptide corresponding to a sequence at the N-terminal of human SKP2, different from the related rat and mouse sequence by three amino acids.
纯化 Immunogen affinity purified.
抗体形式 Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
稳定性与存储 Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
注意事项 Conditions of optimal SKP2 antibody performance should be determined experimentally by the investigator.
线下下单 Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

描述

PA000235-PA1102: SKP2 Polyclonal Antibody
Background

The F box protein Skp2 (S-phase kinase-associated protein 2) is oncogenic, and its frequent amplification and overexpression correlate with the grade of malignancy of certain tumors. Skp2 controls p300-p53 signaling pathways in cancer cells, making it a potential molecular target for cancer therapy. This gene positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. This study provides evidence of a role for an F-box protein in oncogenesis and establishes SKP2 as a protooncogene causally involved in the pathogenesis of lymphomas.
SKP2 Enzyme:
Recombinant Human SKP2

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