CDX2 Polyclonal Antibody
Conditions of optimal CDX2 polyclonal antibody performance should be determined experimentally by the investigator.
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货号 | PA001142-R12-2609 |
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产品名称 | CDX2 Polyclonal Antibody |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | caudal type homeo box transcription factor 2; Caudal-type homeobox protein 2; CDX-3; CDX3; Homeobox protein CDX-2 |
特异性 | CDX2 antibody detects endogenous levels of CDX2. |
反应性 | Human, Mouse, Rat. |
免疫源 | The antiserum was produced against synthesized peptide derived from human CDX2. |
纯化 | The antibody was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography. |
抗体形式 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
稳定性与存储 | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
注意事项 | Conditions of optimal CDX2 antibody performance should be determined experimentally by the investigator. |
线下下单 | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
描述
PA001142-R12-2609: CDX2 Polyclonal Antibody
Introduction
Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The protein encoded by this gene is a homeobox transcription factor. Cdx2 is the gene that directs early embryogenesis in mice. It is required to form the placenta. Ectopic expression of CDX2 was reported more than 85% of the human patients with Acute myeloid leukemia (AML). Ectopic expression of Cdx2 in murine bone marrow induced AML in mice and upregulate Hox genes in bone marrow progenitors.[3][3][4] CDX2 is also implicated in the pathogenesis of Barrett’s esophagus were it has been shown that components from gastroesofageal reflux such as bile acids are able to induce the expression of an intestinal differentiation program through up-regulation of NF-?B and CDX2.
Other CDX2 Antibody:
CDX2 (Ab-283) Polyclonal Antibody