CBL (Ab-774) Polyclonal Antibody
Conditions of optimal CBL (ab-774) polyclonal antibody performance should be determined experimentally by the investigator.
- 产品描述
- 描述
- More Offers
货号 | PA001036-B0464 |
---|---|
产品名称 | CBL (Ab-774) Polyclonal Antibody |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | CBL E3 ubiquitin protein ligase, CBL2, EC 6.3.2.-, Proto-oncogene c-CBL, Signal transduction protein CBL |
特异性 | CBL (Ab-774) antibody detects endogenous levels of total CBL protein. |
反应性 | Human, Mouse, Rat. |
免疫源 | The antiserum was produced against synthesized non-phosphopeptide derived from human CBL around the phosphorylation site of tyrosine 774 (D-G-YP-D-V). |
纯化 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体形式 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
稳定性与存储 | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
注意事项 | Conditions of optimal CBL antibody performance should be determined experimentally by the investigator. |
线下下单 | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
描述
PA001036-B0464: CBL (Ab-774) Polyclonal Antibody
Background
CBL(Cbl proto-oncogene) is also known as C-CBL, RNF55, CBL2 and E3 ubiquitin protein ligase. Wei et al. (1990) mapped the CBL gene to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Other CBL Antibodys:
CBL Polyclonal Antibody
CBL (Ab-700) Polyclonal Antibody
CBL (Ab-674) Polyclonal Antibody