Caspase 10 Polyclonal Antibody
Conditions of optimal caspase 10 polyclonal antibody performance should be determined experimentally by the investigator.
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| 货号 | PA001015-C0135 |
|---|---|
| 产品名称 | Caspase 10 Polyclonal Antibody |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | 悉得（Syd Labs） |
| 别称 | ALPS2; CASP10B; FLICE2, Caspase 10 isoform a preproprotein, Caspase 10 isoform b preproprotein |
| 特异性 | Caspase 10 antibody detects endogenous levels of total Caspase 10 protein. |
| 反应性 | Human. |
| 免疫源 | The antiserum was produced against synthesized peptide derived from human Caspase 10. |
| 纯化 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体形式 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 稳定性与存储 | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| 注意事项 | Conditions of optimal Caspase 10 antibody performance should be determined experimentally by the investigator. |
| 线下下单 | 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com |
描述
PA001015-C0135: Caspase 10 Polyclonal Antibody
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. The Caspase 10 gene contains 11 exons and spans about 48 kb. This gene is mapped to 2q33.1. It is transcribed in the centromere-to-telomere direction.This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
