Biotinylated Human IGF1R/CD221 Protein C-His-Avi Tag | Syd Labs BP005247
(悉得)Syd Labs 货号:BP005247 Biotinylated Human IGF1R/CD221 Protein with the C-His-Avi Tag (生物素化人 IGF1R/CD221 蛋白 c-his-avi 标签) is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Glu31-Asn932.
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货号 | BP005247 |
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产品名称 | Biotinylated Human IGF1R/CD221 Protein C-His-Avi Tag | Syd Labs BP005247 |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216 |
物种 | Human |
来源 | The recombinant Biotinylated Human IGF1R/CD221 Protein, (amino acids Glu31-Asn932) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells. |
Accession | P08069 |
产品标签 | C-His-Avi |
生物素化 | yes |
确定序列 | Glu31-Asn932 |
分子量 | The recombinant Biotinylated Human IGF1R/CD221 protein with the His-Avi tag at the C-terminus has a predicted MW of 105.8 kDa (alpha subunit) and 23 kDa (beta subunit). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result. |
活性 | Immobilized recombinant Biotinylated Human IGF1R protein with the C-His-Avi tag at 1 ug/ml (100 ul/Well) on streptavidin (5 ug/ml) precoated plate. Dose response curve for the recombinant Anti-IGF1R Antibody protein with the C-hFc tag with the EC50 of 3.9 ng/ml determined by ELISA (QC Test). |
Form | Lyophilized |
形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
制剂 | It is recommended to reconstitute the lyophilized recombinant Biotinylated Human IGF1R/CD221 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
运输 | The recombinant Biotinylated Human IGF1R/CD221 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.; -20 to -80°C for 3-6 months in unopened state after reconstitution.; 2-8°C for 2-7 days after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
注意事项 | Conditions of optimal recombinant Biotinylated Human IGF1R/CD221 Protein performance should be determined experimentally by the investigator. |
线下下单 | 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com或联系我们 |
描述
BP005247: Biotinylated Human IGF1R/CD221 Protein with the C-His-Avi Tag (生物素化人 IGF1R/CD221 蛋白 c-his-avi 标签)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
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