BCOR Polyclonal Antibody
Conditions of optimal BCOR polyclonal antibody performance should be determined experimentally by the investigator.
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| 货号 | PA000908-R12-2542 |
|---|---|
| 产品名称 | BCOR Polyclonal Antibody |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | 悉得（Syd Labs） |
| 别称 | BCL-6 corepressor |
| 同种型 | Human IgG4 kappa. |
| 特异性 | BCOR antibody detects endogenous levels of BCOR. |
| 反应性 | Human, Mouse. |
| 免疫源 | The antiserum was produced against synthesized peptide derived from human BCOR. |
| 纯化 | The antibody was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography. |
| 抗体形式 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 稳定性与存储 | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
| 注意事项 | Conditions of optimal BCOR antibody performance should be determined experimentally by the investigator. |
| 线下下单 | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
描述
PA000908-R12-2542: BCOR Polyclonal Antibody
Introduction
BCL-6 corepressor is a protein that in humans is encoded by the BCOR gene.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. At least four alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Mutations in the BCOR gene cause a form of syndromic microphthalmia (small eye) called MCOPS2. This syndrome incorporates microphthalmia, congenital cataracts, cardiac defects, dental defects and skeletal anomalies. Mutations in this gene have also been found associated to acute myeloid leukemia.
Other BCOR Antibody:
BCOR Polyclonal Antibody
